Near its southern terminus, I-29 is concurrent with I-35 and U.S. Route 71. The interstate diverts from U.S. 71 just north of St. Joseph and follows a sparsely populated corridor along the Missouri River to Council Bluffs. During the design phase there was an alternative sending the route further along U.S. 71 through the bigger towns of Maryville, Missouri and Clarinda, Iowa. During the Great Flood of 1993 the Missouri River flooded this section and traffic was rerouted to U.S. 71 through Maryville and Clarinda.
Almost all of I-29 in Missouri is an area called the Platte Purchase that was not originally part of Missouri when it entered the union.